06 sierpnia 2013

Fwd: PNAS Table of Contents for 6 August 2013; Vol. 110, No. 32



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Date: Tue, Aug 6, 2013 at 7:24 PM
Subject: PNAS Table of Contents for 6 August 2013; Vol. 110, No. 32
To: pascal.alter@gmail.com


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Proceedings of the National Academy of Sciences

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This Week in PNAS

In This Issue

Letters (Online Only)

Entropic forces between fluid layers
Håkan Wennerström, Ulf Olsson, and Jacob N. Israelachvili
Reply to Wennerström et al.: Entropic forces on a confined membrane
L. B. Freund
Identifying anagenesis and cladogenesis in the fossil record
Tracy Aze, Thomas H. G. Ezard, Andy Purvis, Helen K. Coxall, Duncan R. M. Stewart, Bridget S. Wade, and Paul N. Pearson
Reply to Aze et al.: Distinguishing speciation modes based on multiple lines of evidence
Luke C. Strotz and Andrew P. Allen
Interpreting the evidence for middle Holocene gene flow from India to Australia
Michael Holton Price and Douglas W. Bird
Reply to Price and Bird: No inconsistency between the date of gene flow from India and the Australian archaeological record
Irina Pugach and Mark Stoneking

Retrospective

Ken Wilson: A scientific appreciation
Frank A. Wilczek

Profile

Profile of Bruce A. Beutler
Sandeep Ravindran

Commentaries

Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation
Mary Elizabeth Patti
Air pollution and life expectancy in China and beyond
C. Arden Pope III and Douglas W. Dockery
ATPase as a switch in PII signal transduction
Cheng-Cai Zhang and Cong-Zhao Zhou

PNAS Plus Significance Statements

PNAS Plus Significance Statements

Perspective

NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers
Ashok Sekhar and Lewis E. Kay

Physical Sciences

Applied Mathematics

Nuclear dynamics in a fungal chimera
Marcus Roper, Anna Simonin, Patrick C. Hickey, Abby Leeder, and N. Louise Glass

Applied Physical Sciences

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
Christopher A. Alabi, Kevin T. Love, Gaurav Sahay, Hao Yin, Kathryn M. Luly, Robert Langer, and Daniel G. Anderson
Polysaccharide hydrogels with tunable stiffness and provasculogenic properties via α-helix to β-sheet switch in secondary structure OPEN ACCESS ARTICLE
Aurelien Forget, Jon Christensen, Steffen Lüdeke, Esther Kohler, Simon Tobias, Maziar Matloubi, Ralf Thomann, and V. Prasad Shastri
Universal collapse of stress and wrinkle-to-scar transition in spherically confined crystalline sheets
Gregory M. Grason and Benny Davidovitch

Astronomy

Crystallization of CO2 ice and the absence of amorphous CO2 ice in space
Rafael M. Escribano, Guillermo M. Muñoz Caro, Gustavo A. Cruz-Diaz, Yamilet Rodríguez-Lazcano, and Belén Maté

Chemistry

Testing the diffusing boundary model for the helix–coil transition in peptides OPEN ACCESS ARTICLE
Sabine Neumaier, Andreas Reiner, Maren Büttner, Beat Fierz, and Thomas Kiefhaber
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
Kimberly E. Beatty, Monique Williams, Brian L. Carlson, Benjamin M. Swarts, Robin M. Warren, Paul D. van Helden, and Carolyn R. Bertozzi
Determining complete electron flow in the cofactor photoreduction of oxidized photolyase OPEN ACCESS ARTICLE
Zheyun Liu, Chuang Tan, Xunmin Guo, Jiang Li, Lijuan Wang, Aziz Sancar, and Dongping Zhong
Dynamic determination of the functional state in photolyase and the implication for cryptochrome OPEN ACCESS ARTICLE
Zheyun Liu, Meng Zhang, Xunmin Guo, Chuang Tan, Jiang Li, Lijuan Wang, Aziz Sancar, and Dongping Zhong
Role of methyl-induced polarization in ion binding
Mariana Rossi, Alexandre Tkatchenko, Susan B. Rempe, and Sameer Varma
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
Hernani Leonardo Silvestre, Thomas L. Blundell, Chris Abell, and Alessio Ciulli

Earth, Atmospheric, and Planetary Sciences

Large Pt anomaly in the Greenland ice core points to a cataclysm at the onset of Younger Dryas
Michail I. Petaev, Shichun Huang, Stein B. Jacobsen, and Alan Zindler

Engineering

A cantilever-free approach to dot-matrix nanoprinting
Keith A. Brown, Daniel J. Eichelsdoerfer, Wooyoung Shim, Boris Rasin, Boya Radha, Xing Liao, Abrin L. Schmucker, Guoliang Liu, and Chad A. Mirkin
Encoded multisite two-photon microscopy
Mathieu Ducros, Yannick Goulam Houssen, Jonathan Bradley, Vincent de Sars, and Serge Charpak

Environmental Sciences

Resilience of river flow regimes OPEN ACCESS ARTICLE
Gianluca Botter, Stefano Basso, Ignacio Rodriguez-Iturbe, and Andrea Rinaldo

Statistics

Inverse Gillespie for inferring stochastic reaction mechanisms from intermittent samples
Ishanu Chattopadhyay, Anna Kuchina, Gürol M. Süel, and Hod Lipson
Statistical significance of combinatorial regulations OPEN ACCESS ARTICLE
Aika Terada, Mariko Okada-Hatakeyama, Koji Tsuda, and Jun Sese

Social Sciences

Economic Sciences

Advertisements impact the physiological efficacy of a branded drug
Emir Kamenica, Robert Naclerio, and Anup Malani

Environmental Sciences

Evidence on the impact of sustained exposure to air pollution on life expectancy from China's Huai River policy OPEN ACCESS ARTICLE
Yuyu Chen, Avraham Ebenstein, Michael Greenstone, and Hongbin Li

Sustainability Science

Evidence on the impact of sustained exposure to air pollution on life expectancy from China's Huai River policy OPEN ACCESS ARTICLE
Yuyu Chen, Avraham Ebenstein, Michael Greenstone, and Hongbin Li

Biological Sciences

Applied Biological Sciences

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1
Durga N. Tripathi, Rajdeep Chowdhury, Laura J. Trudel, Andrew R. Tee, Rebecca S. Slack, Cheryl Lyn Walker, and Gerald N. Wogan
Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
Christopher A. Alabi, Kevin T. Love, Gaurav Sahay, Hao Yin, Kathryn M. Luly, Robert Langer, and Daniel G. Anderson

Biochemistry

Cost of rNTP/dNTP pool imbalance at the replication fork OPEN ACCESS ARTICLE
Nina Y. Yao, Jeremy W. Schroeder, Olga Yurieva, Lyle A. Simmons, and Mike E. O'Donnell
PII signal transduction proteins are ATPases whose activity is regulated by 2-oxoglutarate
Martha V. Radchenko, Jeremy Thornton, and Mike Merrick
Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis
Jaeheon Lee, Yue Hao, Patricia M. Blair, Joel O. Melby, Vinayak Agarwal, Brandon J. Burkhart, Satish K. Nair, and Douglas A. Mitchell
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
Veli-Matti Leppänen, Denis Tvorogov, Kaisa Kisko, Andrea E. Prota, Michael Jeltsch, Andrey Anisimov, Sandra Markovic-Mueller, Edward Stuttfeld, Kenneth N. Goldie, Kurt Ballmer-Hofer, and Kari Alitalo

Biophysics and Computational Biology

Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 Å resolution OPEN ACCESS ARTICLE
Xue Fei, Dong Yang, Nicole LaRonde-LeBlanc, and George H. Lorimer
Testing the diffusing boundary model for the helix–coil transition in peptides OPEN ACCESS ARTICLE
Sabine Neumaier, Andreas Reiner, Maren Büttner, Beat Fierz, and Thomas Kiefhaber
Determining complete electron flow in the cofactor photoreduction of oxidized photolyase OPEN ACCESS ARTICLE
Zheyun Liu, Chuang Tan, Xunmin Guo, Jiang Li, Lijuan Wang, Aziz Sancar, and Dongping Zhong
Dynamic determination of the functional state in photolyase and the implication for cryptochrome OPEN ACCESS ARTICLE
Zheyun Liu, Meng Zhang, Xunmin Guo, Chuang Tan, Jiang Li, Lijuan Wang, Aziz Sancar, and Dongping Zhong
Role of methyl-induced polarization in ion binding
Mariana Rossi, Alexandre Tkatchenko, Susan B. Rempe, and Sameer Varma
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
Hernani Leonardo Silvestre, Thomas L. Blundell, Chris Abell, and Alessio Ciulli
Inverse Gillespie for inferring stochastic reaction mechanisms from intermittent samples
Ishanu Chattopadhyay, Anna Kuchina, Gürol M. Süel, and Hod Lipson
Statistical significance of combinatorial regulations OPEN ACCESS ARTICLE
Aika Terada, Mariko Okada-Hatakeyama, Koji Tsuda, and Jun Sese
Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2′-O-transphosphorylation
Hong Gu, Shuming Zhang, Kin-Yiu Wong, Brian K. Radak, Thakshila Dissanayake, Daniel L. Kellerman, Qing Dai, Masaru Miyagi, Vernon E. Anderson, Darrin M. York, Joseph A. Piccirilli, and Michael E. Harris
Importance of lipid–pore loop interface for potassium channel structure and function
Elwin A. W. van der Cruijsen, Deepak Nand, Markus Weingarth, Alexander Prokofyev, Sönke Hornig, Abhishek Arun Cukkemane, Alexandre M. J. J. Bonvin, Stefan Becker, Raymond E. Hulse, Eduardo Perozo, Olaf Pongs, and Marc Baldus

Cell Biology

Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion
Stéphane G. Rolland, Elisa Motori, Nadin Memar, Jürgen Hench, Stephan Frank, Konstanze F. Winklhofer, and Barbara Conradt
Activation-induced cytidine deaminase (AID) is necessary for the epithelial–mesenchymal transition in mammary epithelial cells
Denise P. Muñoz, Elbert L. Lee, Sachiko Takayama, Jean-Philippe Coppé, Seok-Jin Heo, Dario Boffelli, Javier M. Di Noia, and David I. K. Martin
Polysaccharide hydrogels with tunable stiffness and provasculogenic properties via α-helix to β-sheet switch in secondary structure OPEN ACCESS ARTICLE
Aurelien Forget, Jon Christensen, Steffen Lüdeke, Esther Kohler, Simon Tobias, Maziar Matloubi, Ralf Thomann, and V. Prasad Shastri
Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria
Hyun-Jung An, Geunyoung Cho, Jie-Oh Lee, Sang-Gi Paik, Young Sang Kim, and Hayyoung Lee
Pds5 promotes and protects cohesin acetylation
Kok-Lung Chan, Thomas Gligoris, William Upcher, Yuki Kato, Katsuhiko Shirahige, Kim Nasmyth, and Frédéric Beckouët
Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
Alka Choudhary, Robert F. Lera, Melissa L. Martowicz, Kim Oxendine, Jennifer J. Laffin, Beth A. Weaver, and Mark E. Burkard

Developmental Biology

Pattern reorganization occurs independently of cell division during Drosophila wing disc regeneration in situ OPEN ACCESS ARTICLE
Sandra Díaz-García and Antonio Baonza
Unique insights into maternal mitochondrial inheritance in mice
Shi-Ming Luo, Zhao-Jia Ge, Zhong-Wei Wang, Zong-Zhe Jiang, Zhen-Bo Wang, Ying-Chun Ouyang, Yi Hou, Heide Schatten, and Qing-Yuan Sun

Ecology

Single pollinator species losses reduce floral fidelity and plant reproductive function
Berry J. Brosi and Heather M. Briggs
Context-dependent hierarchies in pigeons
Máté Nagy, Gábor Vásárhelyi, Benjamin Pettit, Isabella Roberts-Mariani, Tamás Vicsek, and Dora Biro
Recent burning of boreal forests exceeds fire regime limits of the past 10,000 years
Ryan Kelly, Melissa L. Chipman, Philip E. Higuera, Ivanka Stefanova, Linda B. Brubaker, and Feng Sheng Hu

Environmental Sciences

Variations in atmospheric CO2 growth rates coupled with tropical temperature
Weile Wang, Philippe Ciais, Ramakrishna R. Nemani, Josep G. Canadell, Shilong Piao, Stephen Sitch, Michael A. White, Hirofumi Hashimoto, Cristina Milesi, and Ranga B. Myneni

Evolution

Capturing the mutational landscape of the beta-lactamase TEM-1
Hervé Jacquier, André Birgy, Hervé Le Nagard, Yves Mechulam, Emmanuelle Schmitt, Jérémy Glodt, Beatrice Bercot, Emmanuelle Petit, Julie Poulain, Guilène Barnaud, Pierre-Alexis Gros, and Olivier Tenaillon

Immunology

Advertisements impact the physiological efficacy of a branded drug
Emir Kamenica, Robert Naclerio, and Anup Malani
Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease OPEN ACCESS ARTICLE
Arnold Han, Evan W. Newell, Jacob Glanville, Nielsen Fernandez-Becker, Chaitan Khosla, Yueh-hsiu Chien, and Mark M. Davis
Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance
Saul J. Priceman, Maciej Kujawski, Shudan Shen, Gregory A. Cherryholmes, Heehyoung Lee, Chunyan Zhang, Laura Kruper, Joanne Mortimer, Richard Jove, Arthur D. Riggs, and Hua Yu
Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells
Arnaud Pommier, Alexandra Audemard, Aurélie Durand, Renée Lengagne, Arnaud Delpoux, Bruno Martin, Laetitia Douguet, Armelle Le Campion, Masashi Kato, Marie-Françoise Avril, Cédric Auffray, Bruno Lucas, and Armelle Prévost-Blondel
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer
Lidia Bosurgi, Jochem H. Bernink, Victor Delgado Cuevas, Nicola Gagliani, Leonel Joannas, Edward T. Schmid, Carmen J. Booth, Sourav Ghosh, and Carla V. Rothlin
Teleost skin, an ancient mucosal surface that elicits gut-like immune responses
Zhen Xu, David Parra, Daniela Gómez, Irene Salinas, Yong-An Zhang, Louise von Gersdorff Jørgensen, Rasmus Demuth Heinecke, Kurt Buchmann, Scott LaPatra, and J. Oriol Sunyer

Medical Sciences

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent OPEN ACCESS ARTICLE
Mark Merchant, Xiaolei Ma, Henry R. Maun, Zhong Zheng, Jing Peng, Mally Romero, Arthur Huang, Nai-ying Yang, Merry Nishimura, Joan Greve, Lydia Santell, Yu-Wen Zhang, Yanli Su, Dafna W. Kaufman, Karen L. Billeci, Elaine Mai, Barbara Moffat, Amy Lim, Eileen T. Duenas, Heidi S. Phillips, Hong Xiang, Judy C. Young, George F. Vande Woude, Mark S. Dennis, Dorothea E. Reilly, Ralph H. Schwall, Melissa A. Starovasnik, Robert A. Lazarus, and Daniel G. Yansura
Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis
Rituparna Das, Mi-Sun Koo, Bae Hoon Kim, Shevin T. Jacob, Selvakumar Subbian, Jie Yao, Lin Leng, Rebecca Levy, Charles Murchison, William J. Burman, Christopher C. Moore, W. Michael Scheld, John R. David, Gilla Kaplan, John D. MacMicking, and Richard Bucala
Single-dose vaccine against tick-borne encephalitis OPEN ACCESS ARTICLE
Alexander A. Rumyantsev, Ana P. Goncalvez, Maryann Giel-Moloney, John Catalan, Yuxi Liu, Qing-sheng Gao, Jeff Almond, Harry Kleanthous, and Konstantin V. Pugachev
Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells
Vedashree Ramakrishnaiah, Christine Thumann, Isabel Fofana, Francois Habersetzer, Qiuwei Pan, Petra E. de Ruiter, Rob Willemsen, Jeroen A. A. Demmers, Victor Stalin Raj, Guido Jenster, Jaap Kwekkeboom, Hugo W. Tilanus, Bart L. Haagmans, Thomas F. Baumert, and Luc J. W. van der Laan

Microbiology

Nuclear dynamics in a fungal chimera
Marcus Roper, Anna Simonin, Patrick C. Hickey, Abby Leeder, and N. Louise Glass
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
Kimberly E. Beatty, Monique Williams, Brian L. Carlson, Benjamin M. Swarts, Robin M. Warren, Paul D. van Helden, and Carolyn R. Bertozzi
Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity
Rong Zhang, Babal K. Jha, Kristen M. Ogden, Beihua Dong, Ling Zhao, Ruth Elliott, John T. Patton, Robert H. Silverman, and Susan R. Weiss
Rapid and robust signaling in the CsrA cascade via RNA–protein interactions and feedback regulation
David Nellinger Adamson and Han N. Lim
Nucleosome maps of the human cytomegalovirus genome reveal a temporal switch in chromatin organization linked to a major IE protein
Einat Zalckvar, Christina Paulus, Desiree Tillo, Alexandra Asbach-Nitzsche, Yaniv Lubling, Carla Winterling, Nicholas Strieder, Katrin Mücke, Felicia Goodrum, Eran Segal, and Michael Nevels
A riboswitch-regulated antisense RNA in Listeria monocytogenes OPEN ACCESS ARTICLE
J. R. Mellin, Teresa Tiensuu, Christophe Bécavin, Edith Gouin, Jörgen Johansson, and Pascale Cossart

Neuroscience

In vivo synaptic recovery following optogenetic hyperstimulation
Maike Kittelmann, Jana F. Liewald, Jan Hegermann, Christian Schultheis, Martin Brauner, Wagner Steuer Costa, Sebastian Wabnig, Stefan Eimer, and Alexander Gottschalk
SOX2–LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors
Flavio Cimadamore, Alejandro Amador-Arjona, Connie Chen, Chun-Teng Huang, and Alexey V. Terskikh
Targeting H3K4 trimethylation in Huntington disease
Malini Vashishtha, Christopher W. Ng, Ferah Yildirim, Theresa A. Gipson, Ian H. Kratter, Laszlo Bodai, Wan Song, Alice Lau, Adam Labadorf, Annie Vogel-Ciernia, Juan Troncosco, Christopher A. Ross, Gillian P. Bates, Dimitri Krainc, Ghazaleh Sadri-Vakili, Steven Finkbeiner, J. Lawrence Marsh, David E. Housman, Ernest Fraenkel, and Leslie M. Thompson
Encoded multisite two-photon microscopy
Mathieu Ducros, Yannick Goulam Houssen, Jonathan Bradley, Vincent de Sars, and Serge Charpak
Oscillatory activity in the monkey hippocampus during visual exploration and memory formation
Michael J. Jutras, Pascal Fries, and Elizabeth A. Buffalo
Adult pallium transcriptomes surprise in not reflecting predicted homologies across diverse chicken and mouse pallial sectors OPEN ACCESS ARTICLE
T. Grant Belgard, Juan F. Montiel, Wei Zhi Wang, Fernando García-Moreno, Elliott H. Margulies, Chris P. Ponting, and Zoltán Molnár
Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues
Eugene L. Dimitrov, Jonathan Kuo, Kenji Kohno, and Ted B. Usdin
Stimulus-dependent variability and noise correlations in cortical MT neurons
Adrián Ponce-Alvarez, Alexander Thiele, Thomas D. Albright, Gene R. Stoner, and Gustavo Deco
Word learning is mediated by the left arcuate fasciculus
Diana López-Barroso, Marco Catani, Pablo Ripollés, Flavio Dell'Acqua, Antoni Rodríguez-Fornells, and Ruth de Diego-Balaguer

Physiology

Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity
Rajan Sah, Pietro Mesirca, Marjolein Van den Boogert, Jonathan Rosen, John Mably, Matteo E. Mangoni, and David E. Clapham
Shear stress activation of nuclear receptor PXR in endothelial detoxification
Xiaohong Wang, Xi Fang, Jing Zhou, Zhen Chen, Beilei Zhao, Lei Xiao, Ao Liu, Yi-Shuan J. Li, John Y.-J. Shyy, Youfei Guan, Shu Chien, and Nanping Wang
Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening
Mark A. Zaydman, Jonathan R. Silva, Kelli Delaloye, Yang Li, Hongwu Liang, H. Peter Larsson, Jingyi Shi, and Jianmin Cui
Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy OPEN ACCESS ARTICLE
Julia V. Gerasimenko, Oleksiy Gryshchenko, Pawel E. Ferdek, Eloise Stapleton, Tania O. G. Hébert, Solomiia Bychkova, Shuang Peng, Malcolm Begg, Oleg V. Gerasimenko, and Ole H. Petersen

Plant Biology

Convergence of auxin and gibberellin signaling on the regulation of the GATA transcription factors GNC and GNL in Arabidopsis thaliana
René Richter, Carina Behringer, Melina Zourelidou, and Claus Schwechheimer
Six-rowed spike4 (Vrs4) controls spikelet determinacy and row-type in barley OPEN ACCESS ARTICLE
Ravi Koppolu, Nadia Anwar, Shun Sakuma, Akemi Tagiri, Udda Lundqvist, Mohammad Pourkheirandish, Twan Rutten, Christiane Seiler, Axel Himmelbach, Ruvini Ariyadasa, Helmy Mohamad Youssef, Nils Stein, Nese Sreenivasulu, Takao Komatsuda, and Thorsten Schnurbusch
Single-particle analysis reveals shutoff control of the Arabidopsis ammonium transporter AMT1;3 by clustering and internalization OPEN ACCESS ARTICLE
Qinli Wang, Yuanyuan Zhao, Wangxi Luo, Ruili Li, Qihua He, Xiaohong Fang, Roberto De Michele, Cindy Ast, Nicolaus von Wirén, and Jinxing Lin
Ultradian metabolic rhythm in the diazotrophic cyanobacterium Cyanothece sp. ATCC 51142
Jan Červený, Maria A. Sinetova, Luis Valledor, Louis A. Sherman, and Ladislav Nedbal

Psychological and Cognitive Sciences

Bottlenose dolphins can use learned vocal labels to address each other
Stephanie L. King and Vincent M. Janik

Systems Biology

Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder OPEN ACCESS ARTICLE
Christine Ecker, Lisa Ronan, Yue Feng, Eileen Daly, Clodagh Murphy, Cedric E. Ginestet, Michael Brammer, Paul C. Fletcher, Edward T. Bullmore, John Suckling, Simon Baron-Cohen, Steve Williams, Eva Loth, MRC AIMS Consortium, and Declan G. M. Murphy

Corrections

Correction for Currie and Schwandt, Within-mother analysis of seasonal patterns in health at birth
Correction for Chow et al., Rhythmic alternating patterns of brain activity distinguish rapid eye movement sleep from other states of consciousness
Correction for Li et al., Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
Correction for Liebrand et al., Receptor-like kinase SOBIR1/EVR interacts with receptor-like proteins in plant immunity against fungal infection

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Fwd: Moment of Happiness -- The Happiness Project



---------- Forwarded message ----------
From: Gretchen Rubin <gretchenhappinessquotes@gmail.com>
Date: Tue, Aug 6, 2013 at 1:56 PM
Subject: Moment of Happiness -- The Happiness Project
To: pascal.alter@gmail.com


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Fwd: Excavators,telehandlers,vehicles



---------- Forwarded message ----------
From: Mullan Plant Sales <mail@webmanagementconsultants.com>
Date: Tue, Aug 6, 2013 at 11:50 AM
Subject: Excavators,telehandlers,vehicles
To: pascal.alter@gmail.com


 
Mullan Plant Sales
Mullan Plant Sales Head Office: +44 (0)28 295 58605
Eugene Mullan: +44 (0)7968 948326
Daniel Mullan: +44 (0)7821324711
   10-12 Carhill Road, Garvagh, Coleraine, N Ireland, BT51 5NJ    Email: reception@mullanautosales.com
--------

Latest Stock - 6th August 2013

Please click on the images below for additional details and more pics.

Komatsu PC210LC-8

Komatsu PC210LC-8
One owner from new. Looks and operates like new. Year 2011 with 966 hours. Undercarriage and paintwork excellent. Check valves, hammer piping, hydraulic quick coupler, two way piping, reverse camera, vandal gaurds, fully serviced and ready for immediate operation. Good saving on new price. AVAILABLE TODAY
£75,000.00

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Hitachi ZX210LC-3

Hitachi ZX210LC-3
One owner from new. Looks and operates like new. Year 2013 with 800 hours. Undercarriage and paintwork excellent. Check valves, hammer piping, hydraulic quick coupler, bucket, reverse camera, vandal gaurds, fully serviced and ready for immediate operation. AVAILABLE TODAY
£86,000.00

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Hitachi ZX210LC-3

Hitachi ZX210LC-3
One owner from new. Looks and operates like new. Year 2012 with 1500 hours. Undercarriage and paintwork excellent. Check valves, hammer piping, hydraulic quick coupler, bucket, reverse camera, vandal gaurds, fully serviced and ready for immediate operation. Good saving on new price.
£79,500.00

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JCB 530-120

JCB 530-120
One local farmer owner from new. In excellent condition. 4282 Genuine hours. Paintwork excellent, interior excellent, tires excellent. Just after a full service. Working very well and is ready for immediate operation. Genuine good machine all around.
£10,500.00

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JCB 540-70 Waste Master

JCB 540-70 Waste Master
Owned by local council from new. Well maintained and cared for. Waste master specification including 15.5 x 25 Michelin Tires, Powershift, single joystick control, quick release bucket and forks, low hours. Can lift 4 tonnes and has a 7 meter reach. In good condition inside and outside. Ready for immediate operation.
£18,995.00

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Volvo EC25

Volvo EC25
One owner from new. Hammer piping. Hitch. 3 good buckets. Original paintwork. Excellent rubber tracks. Good undercarriage. In very good condition inside and out. Low hours. Ready for immediate operation.
£9,750.00

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JCB 3CX Contractor

JCB 3CX Contractor
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JCB 520-40

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Komatsu PC88MR-6

Komatsu PC88MR-6
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Manitou MT1436R

Manitou MT1436R
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Manitou MT1436R

Manitou MT1436R
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JCB 537-135

JCB 537-135
NEW MODEL 537-135. Can lift 3.7 Tonne with a reach of 13.5 meters. Good tires. Complete with forks and tipping skip attachment. Ready for immediate use.
£POA

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Volvo EC25

Volvo EC25
One owner from new. 2700 genuine hours. New Rubber tracks. Original good paintwork. Interior in good condition. Hitch and 3 Buckets. Working well. Ready for immediate operation.
£POA

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Komatsu PC210LC-7

Komatsu PC210LC-7
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JCB 533-105

JCB 533-105
One owner from new. Good condition inside and outside. Good tires. 3.3T lift capacity and 10M reach. Low hours and Air conditioning.
£32,500.00

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JCB 535-140 HiViz

JCB 535-140 HiViz
One owner from new. Over sized wheels. Original good paintwork. Good tires. Air conditioning. Well maintained and looked after. Ready for immediate use.
£37,000.00

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Komatsu PC210LC-8

Komatsu PC210LC-8
One owner from new, in good condition inside and outside. Undercarriage in good working order, Hydraulic quick hitch, hammer piping, rotator piping, shear piping. Ready for immediate operation.
£52,000.00

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Manitou MT1740 SLT

Manitou MT1740 SLT
One owner from new. Well maintained and looked after. Original paintwork. Exterior and interior in good condition. Genuine low hours. Turbo engine and sway control. Nice machine. Ready for immediate operation.
£17,995.00

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Iveco Eurocargo 260 E28 HIAB Grab Tipper

Iveco Eurocargo 260 E28 HIAB Grab Tipper
Owned from new by the Scottish Power Board. Full maintenance from new. In excellent condition with only 104,000 KMS. 6x4 Thompson Steel Body Tipper c/w HIAB 085L grab. Ready for immediate operation.
£POA

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Komatsu PC130-8

Komatsu PC130-8
One owner from new. Full service history. Hammer piped, rotar piped, shear piped, air con, rubber city blocks. Well maintained and looked after. Ready for immediate operation.
£33,250.00

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05 sierpnia 2013

Fwd: Phys.org Newsletter Friday, Aug 2



---------- Forwarded message ----------
From: Newsletter Phys.org <not-for-reply@physorg.com>
Date: Sat, Aug 3, 2013 at 2:03 AM
Subject: Phys.org Newsletter Friday, Aug 2
To: Pascal Alter <pascal.alter@gmail.com>


Dear Pascal Alter,

Here is your customized Phys.org Newsletter for August 2, 2013:

Spotlight Stories Headlines

- New coating turns ordinary glass into super glass
- A cometary graveyard
- Researchers find way to measure speed of spinning object using light's orbital angular momentum
- Whooping cough on the rise again
- Scientists uncover secrets of starfish's bizarre feeding mechanism
- Cobalt replacements make solar cells more sustainable
- Wired for change: Gene expression study reveals first steps of evolution in gene regulation
- Engineers discover unique fingerprint for cell phones
- Japanese companies develop quake damping pendulums for tall buildings
- Predicted experimental test will clarify how light interacts with matter at high energies
- Bio-inspired design may lead to more energy efficient windows
- New findings could help improve development of drugs for addiction
- Archaeologists uncover 200-year-old Alaska village
- Baby owls sleep like baby humans
- Why guppies have genital claws

Space & Earth news

Russia PM reprimands space chief for failures
Prime Minister Dmitry Medvedev on Friday issued an official reprimand to the head of Russia's space agency Roscosmos after a series of embarrassing rocket launch failures.

A waterworld of volcanoes
In 2008, UiB researchers discovered Loki's Castle, a field of five active hydrothermal vents on the Mid-Atlantic Ridge between Norway and Greenland. The field contains rich metal deposits and a unique wildlife.

NASA looks at Tropical Storm Jebi in South China Sea
Tropical Storm Jebi developed on July 31 and NASA satellite data on Aug. 1 shows the storm filling up at least half of the South China Sea.

Next generation of unmanned aircraft to boost geoscientific research
The University of Southampton is developing new unmanned aircraft for science applications and geoscientific research.

Environmental Sample Processors help prevent seafood poisoning
Washington state is one of the nation's most prolific areas for shellfish harvesting and aquaculture. Yet, as in many other areas, Washington's shellfish may cause seafood poisoning when certain types of harmful algae or bacteria become abundant in local waters. From June to September 2013, MBARI researchers are collaborating with government agencies, shellfish growers, and native tribes in the Puget Sound area to test a new method for detecting such "blooms" using MBARI-developed Environmental Sample Processors (ESPs).

Nepal to keep closer eye on Everest expeditions
Nepal's tourism ministry said Friday it plans to exercise tighter control of climbers scaling Mount Everest to make sure they keep the world's highest peak clean and to prevent rows.

Soil carbon 'blowing in the wind'
Top soil is rich in nutrients and carbon but is increasingly being blown away by events such as the 'Red Dawn' in Sydney in 2009.

Water in a Martian desert
Craters once brim-full with sediments and water have long since drained dry, but traces of their former lives as muddy lakes cling on in the Martian desert.

NASA's space launch system completes preliminary design review
NASA has achieved a major milestone in its effort to build the nation's next heavy-lift launch vehicle by successfully completing the Space Launch System (SLS) preliminary design review.

Revised location of 1906 rupture of San Andreas Fault in Portola Valley
New evidence suggests the 1906 earthquake ruptured the San Andreas Fault in a single trace through Portola Village, current day Town of Portola Valley, and indicates a revised location for the fault trace.

Sounding rocket to study active regions on the sun
(Phys.org) —At NASA's White Sands Test Facility in Las Cruces, N.M., a sounding rocket is being readied for flight. Due to launch on Aug. 8, 2013, the VERIS rocket, short for Very high Resolution Imaging Spectrometer, will launch for a 15-minute trip carrying an instrument that can measure properties of the structures in the sun's upper atmosphere down to 145 miles across, some eight times clearer than any similar telescope currently in space.

NASA sees Hurricane Gil being chased by developing storm
On July 31, NASA's TRMM satellite saw Tropical Storm Gil intensifying and the storm became a hurricane. NASA's Aqua satellite and NOAA's GOES-15 satellite captured views of Gil on Aug. 1 as it was being chased by another developing tropical system.

World food security more vulnerable than ever to climate change
A new study, published today (2 August) in Science, has called for a 'climate-smart food system' to prevent climate change from slowing progress in eradicating global hunger.

Project targets coral dredging fallout
Western Australia's marine environment, researchers and the offshore oil and gas industry are set to benefit from new insights provided by a national sea simulator launched at the Australian Institute of Marine Science (AIMS) in Townsville on Thursday.

Decoding material fluxes in the tropical ocean
How is vital oxygen supplied to the tropical ocean? For the first time, oceanographers at GEOMAR Helmholtz Centre for Ocean Research Kiel were able to make quantitative statements regarding this question. They showed that about one third of the oxygen supply in these areas is provided by turbulent processes, such as eddies or internal waves. The study, conducted in the framework of the Collaborative Research Center SFB 754 "Climate-Biogeochemistry Interactions in the Tropical Ocean", was just published in the international journal Biogeosciences.

NASA sees a very active tropical Eastern Pacific Ocean
The Eastern Pacific Ocean has kicked into high gear on Aug. 2 and NOAA's GOES-15 satellite is watching Hurricane Gil and two developing tropical low pressure areas on both sides of Gil.

Mission to build world's most advanced telescope reaches major milestone
(Phys.org) —With the signing last week of a "master agreement" for the Thirty Meter Telescope—destined to be the most advanced and powerful optical telescope in the world—the University of California and UCLA moved a step closer to peering deeper into the cosmos than ever before.

Scientists look into Earth's 'deep time' to predict future effects of climate change
Climate change alters the way in which species interact with one another—a reality that applies not just to today or to the future, but also to the past, according to a paper published by a team of researchers in this week's issue of the journal Science.

Curiosity rover nearing first anniversary on Mars
(Phys.org) —NASA's Curiosity rover will mark one year on Mars next week and has already achieved its main science goal of revealing ancient Mars could have supported life. The mobile laboratory also is guiding designs for future planetary missions.

A cometary graveyard
A team of astronomers from the University of Anitoquia, Medellin, Colombia, have discovered a graveyard of comets. The researchers, led by Anitoquia astronomer Prof. Ignacio Ferrin, describe how some of these objects, inactive for millions of years, have returned to life leading them to name the group the 'Lazarus comets'. The team publish their results in the Oxford University Press journal Monthly Notices of the Royal Astronomical Society.

Medicine & Health news

India's baby Roona discharged after surgeons shrink skull (Update)
Doctors allowed a one-year-old Indian baby to go home Friday after nearly four months of treatment to correct a rare disorder that caused her head to double in size.

Interest grows in New Zealand's designer drug law
A novel New Zealand law that could legalize some designer drugs is being scrutinized with interest by other countries struggling to keep up with the proliferation of "party pills" and similar products.

House OKs 40th effort to repeal health law (Update)
Republicans have pushed legislation through the House preventing the Internal Revenue Service from implementing any part of President Barack Obama's health care overhaul. It's the 40th time the chamber has voted to repeal all or part of the 2010 law.

New Zealand youth engaging in less risky pursuits
Drinking, drugs and other risky behaviours are on the decline according to a nationwide report on New Zealand youth launched at Parliament recently.

Risks of over-the-counter painkillers to Aboriginal people
New research at the University of Adelaide has highlighted serious potential health risks to Aboriginal people because of a lack of understanding about the use of over-the-counter painkillers.

FDA defining what "gluten free" means on packages
Consumers are going to know exactly what they're getting when they buy foods labeled "gluten free."

Why is orange the new black for female victims of trauma?
How do pathways to jail vary for females who are victims of specific types of trauma? New research published in Psychology of Women Quarterly, a SAGE journal, pinpoints the types of trauma such as caregiver violence, witnessing violence, and intimate partner violence, that lead to specific types of offending later in life and offers explanations based on real experiences.

Added benefit of lixisenatide is not proven
Lixisenatide (trade name: Lyxumia) has been approved in Germany since February 2013 for the treatment of type 2 diabetes mellitus in combination with oral blood-glucose lowering drugs or basal insulin when these, together with diet and exercise, do not provide adequate glycaemic control. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new drug offers an added benefit over the current standard therapy. No such added benefit can be derived from the dossier, however, because the drug manufacturer did not present any suitable data for any of the possible therapeutic indications of lixisenatide.

New IOM report lays out plan to determine effectiveness of obesity prevention efforts
The United States lags behind other international plans to evaluate obesity prevention efforts, and the country needs to know whether these efforts are having their intended impact, says a new report from the Institute of Medicine. The committee that wrote the report concluded that more systematic and routine evaluations could help determine how well obesity prevention programs and policies are being implemented and which interventions work best. The committee also recommended specific national and community plans for evaluation of obesity prevention efforts.

Vandetanib in thyroid cancer: Added benefit not proven
Vandetanib (trade name: Caprelsa) has been approved in Germany since February 2012 for the treatment of adult patients who have a particular form of aggressive thyroid cancer. In a new benefit assessment, the German Institute for Quality and Efficiency in Health Care (IQWiG) has now examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG).

Apixaban in atrial fibrillation: Indications of considerable added benefit
The clot-inhibiting drug apixaban (trade name: Eliquis) has been approved in Germany since November 2012 for the prevention of embolism and stroke in adults with non-valvular atrial fibrillation. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined the added benefit of apixaban.

Grape consumption associated with healthier eating patterns in US children and adults
In a new observational study published in the Journal of Food Science, researchers looked at the association of grape consumption, in the non-alcoholic forms most commonly consumed – fresh grapes, raisins and 100% grape juice – with the diet quality of a recent, nationally representative sample of U.S. children and adults. Their findings suggest that, among adults and children, consumption of grapes and grape products is associated with healthier dietary patterns and improved nutrient intakes.

Miss. law requires cord blood from some teen moms
If a girl younger than 16 gives birth in Mississippi and won't name the father, a new state law says authorities must collect umbilical cord blood and run DNA tests to prove paternity.

400 now sickened in stomach bug outbreak
(HealthDay)—The ongoing outbreak of infection with the foodborne cyclospora parasite has now reached 400 cases and spread to 16 states and New York City, according to the latest U.S. Centers for Disease Control and Prevention report issued Friday.

How to stop bleeding in the ER caused by warfarin
Prothrombin complex concentrates (PCCs) are faster and more effective than fresh frozen plasma at reversing hemorrhage caused by the anti-coagulant warfarin, despite plasma being the most commonly used therapy. A literature review published last month in Annals of Emergency Medicine suggests that physicians in the United States should join those around the world in following recommendations of multiple specialty organizations to use PCCs as the first line of defense in this common and life-threatening emergency ("Rapid Reversal of Warfarin-Associated Hemorrhage in the Emergency Department by Prothrombin Complex Concentrates").

The four-point test to predict death risk from C. difficile
A Clostridium difficile (C. diff) infection is one that can affect the digestive system and most commonly affects people staying in hospital. It is not generally a problem for healthy people but may infect those on antibiotics with an imbalance of 'good bacteria' in the gut.

CDC: Breastfeeding rates increasing in US
(HealthDay)—More than three-quarters of infants begin breastfeeding, and rates at six and 12 months have increased since 2000, according to a report published by the U.S. Centers for Disease Control and Prevention.

Will you look more attractive after plastic surgery?
(HealthDay)—Facial plastic surgery may turn back the hands of time, but new research suggests it may not, alas, boost attractiveness.

Dexamethasone beats placebo for cancer-related fatigue
(HealthDay)—For patients with advanced cancer, dexamethasone is better than placebo for reducing cancer-related fatigue (CRF), according to a study published online July 29 in the Journal of Clinical Oncology.

ASID: Doctors may be to blame for antimicrobial resistance
(HealthDay)—The potential roles of animals, airlines, doctors, pharmaceutical companies, and nursing homes in the development of antimicrobial resistance are to be explored in a session at the Australasian Society for Infectious Diseases Gram Negative "Superbug" Meeting, held from Aug. 2 to 3 on the Gold Coast, Australia.

No MI rate advantage for aggressive T2DM glucose control
(HealthDay)—In patients with type 2 diabetes, more aggressive glucose-control strategies have variable short-term effects on microvascular complications, but they do not reduce the rate of myocardial infarction over four years of follow-up, according to a study published online July 22 in Diabetes Care.

APA: iPad use in classroom ups communication in ASD
(HealthDay)—Use of handheld touch devices in classrooms may be beneficial for enhancing communication skills among children with autism spectrum disorders, according to a study presented at the annual meeting of the American Psychological Association, held from July 31 to Aug. 4 in Honolulu.

Lung-protective ventilation ups outcomes post-abdominal op
(HealthDay)—For patients at intermediate to high risk of pulmonary complications after major abdominal surgery, lung-protective ventilation with the use of low tidal volumes and positive end-expiratory pressure is associated with improved clinical outcomes, according to a study published in the Aug. 1 issue of the New England Journal of Medicine.

Alcohol use down, drug use up among pregnant women
(HealthDay)—From 2000 to 2010 there was a decrease in alcohol abuse, but an increase in drug use, among pregnant women, according to a report published July 25 by the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA).

Quality improvement model cuts pressure ulcer rate in PICU
(HealthDay)—A collaborative quality improvement (QI) model can effectively reduce the rate of pressure ulcers (PUs) in the pediatric intensive care unit (PICU), according to a study published in the June 1 issue of Pediatrics.

Fat-cell 'switch' may determine whether body stores energy or burns it
(HealthDay)—Researchers say they've found a "toggle switch" that controls whether fat cells in the body burn up or store their energy.

US gun violence: Murders down, suicides up, CDC reports
(HealthDay)—Fewer people in America's largest cities are being murdered by guns, but the rate of suicide by gun has increased in recent years, U.S. health officials said Thursday.

Rare eye disease leaves people without an iris
(HealthDay)—You may never have heard of aniridia, a genetic disorder that robs people of their vision. But researchers studying the condition say it could give insight into some common health problems—from cataracts and glaucoma to diabetes and obesity.

New study confirms need for state smoke-free laws
American Heart Association CEO Nancy Brown issued the following comments today on the CDC Foundation's new study released in the journal Preventing Chronic Disease, which found smoke-free laws in nine states had no impact on restaurant and bar revenue:

Singles need work / life balance too
(Medical Xpress)—If you think balancing work and family demands is one of the central challenges of modern life, you might be surprised to learn that parents score better than their childless counterparts on the work/life balance scale. 

Secondhand smoke in bars, restaurants increases asthma, cancer risk
In the first study to evaluate the health risks of exposure to secondhand smoke for patrons of restaurants and bars, researchers have found that the risks are well above the acceptable level. The study assessed the risk for lung cancer and heart disease deaths among both patrons and servers and also for asthma initiation—the first study to do so—among servers.

Largest neuronal network simulation to date achieved using Japanese supercomputer
By exploiting the full computational power of the Japanese supercomputer, K Computer, researchers from the RIKEN HPCI Program for Computational Life Sciences, the Okinawa Institute of Technology Graduate University (OIST) in Japan and Forschungszentrum Jülich in Germany have carried out the largest general neuronal network simulation to date.

Tired, moody and pregnant? Exercise may be the answer
Exercise may improve the mood of pregnant women and help to reduce levels of fatigue reports new research published in Psychology & Health. The study, by Anca Gaston and Harry Prapavessis at the University of Western Ontario, examined whether a four week exercise intervention programme would result in improvements in the psychological well-being of previously inactive pregnant women. The results were clear, with participants reporting significant improvements in their mood during the programme. They also saw reduced levels of fatigue, suggesting that pregnant women should be encouraged to engage in regular exercise to improve both psychological and physical well-being.

Researchers identify novel therapy to treat muscular dystrophy
Researchers at Boston University College of Health & Rehabilitation Sciences: Sargent College have identified a combinatorial therapeutic approach that has proven effective in treating muscular dystrophy in a mouse model. The findings, published in Human Molecular Genetics, represent a paradigm shift for the treatment of muscular dystrophy as well as a host of other disabling and devastating muscle diseases.

Software that analyzes sleep patterns without human input could help improve sleep research
Sleep research typically involves recording electroencephalography (EEG) and electromyography (EMG) signals of brain activity over long periods of time, then painstakingly analyzing these records in a process called sleep staging to determine how much time the subject spent in each stage of sleep. Genshiro Sunagawa from the Laboratory for Systems Biology at the RIKEN Center for Developmental Biology and colleagues have now developed a fully automated analysis process that promises to improve the speed and reliability of sleep staging analysis.

Often misidentified, multiracial people value accurate perceptions
Multiracial people may be misidentified more often as being white than black and may value being accurately identified more so than single-race individuals, according to research presented at APA's 121st Annual Convention.

Alcoholism could be linked to a hyper-active brain dopamine system
Research from McGill University suggests that people who are vulnerable to developing alcoholism exhibit a distinctive brain response when drinking alcohol, according to a new study by Prof. Marco Leyton, of McGill University's Department of Psychiatry. Compared to people at low risk for alcohol-use problems, those at high risk showed a greater dopamine response in a brain pathway that increases desire for rewards. These findings, published in the journal Alcoholism: Clinical & Experimental Research, could help shed light on why some people are more at risk of suffering from alcoholism and could mark an important step toward the development of treatment options.

Novel 3-D simulation technology helps surgical residents train more effectively
A novel interactive 3-dimensional(3-D) simulation platform offers surgical residents a unique opportunity to hone their diagnostic and patient management skills, and then have those skills accurately evaluated according to a new study appearing in the August issue of the Journal of the American College of Surgeons. The findings may help establish a new tool for assessing and training surgical residents.

FDA warns of rare skin reactions to acetaminophen
(HealthDay)—The widely used painkiller acetaminophen, best known as Tylenol, can cause rare but serious skin reactions and a warning about this danger will be added to product labels, the U.S. Food and Drug Administration said Thursday.

New findings could influence the development of therapies to treat dengue disease
New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.

Injuries from teen fighting deal a blow to IQ
A new Florida State University study has found that adolescent boys who are hurt in just two physical fights suffer a loss in IQ that is roughly equivalent to missing an entire year of school. Girls experience a similar loss of IQ after only a single fighting-related injury.

Take your child's word for it on asthma, study finds
Children's perceptions of living with asthma may differ significantly from their caregivers' perceptions, which means both should be interviewed when they visit the doctor's office, a new study from UT Kids San Antonio and the Center for Airway Inflammation Research (cAIR) shows.

Pollutants from incense smoke cause human lung-cell inflammation
Burning incense, a popular cultural practice in Arabian Gulf countries and elsewhere, generates indoor air pollutants that may cause inflammation in human lung cells, say researchers in the Gillings School of Global Public Health at the University of North Carolina at Chapel Hill.

India revokes cancer drug patent in fresh industry blow
India has revoked a local patent granted to Britain's GlaxoSmithKline for a breast cancer drug in the latest blow to global companies seeking a bigger presence in the country's $13 billion medicine market.

Researchers develop first successful laboratory model for studying hepatitis C
By differentiating monkey stem cells into liver cells and inducing successful infection, researchers from the Icahn School of Medicine at Mount Sinai have shown for the first time that the hepatitis C virus (HCV) can replicate in monkeys, according to research published in the journal Gastroenterology. The new findings may lead to the first new animal model and provide new avenues for developing treatments and vaccines for this disease, which impacts more than three million people in the United States.

Nonsentinel lymph nodes key factor in melanoma prognosis
(HealthDay)—Nonsentinel lymph node (NSLN) positivity is a significant prognostic factor in patients with stage III melanoma, associated with shorter overall and disease-specific survival, according to research published online July 31 in JAMA Surgery.

Employees less depressed, more anxious in 2013
(HealthDay)—Employees are less depressed but more anxious than last year, with one-third of employees feeling tense or anxious much of the time, according to a report published by the ComPsych Corporation.

High pain sensitivity linked to dry eye disease symptoms
(HealthDay)—Pain sensitivity and pain tolerance are associated with symptoms of dry eye disease (DED), according to a study published online Aug. 1 in JAMA Ophthalmology.

Skin cancer may develop during laser removal of tattoo
(HealthDay)—Malignant melanoma may develop on a preexisting nevus within a tattoo that is being removed with laser therapy, according to a case report published online July 31 in JAMA Dermatology.

Benefits of single-incision laparoscopy unclear
(HealthDay)—There is limited data available to demonstrate the safety and feasibility of minimally invasive, single-incision laparoscopy, according to a technology assessment published in the August issue of Obstetrics & Gynecology.

Childhood abuse linked to later thyroid problems for women
(HealthDay)—Women who suffered physical abuse during childhood are at increased risk for thyroid problems, according to a new study.

Could dietary tweaks ease type 1 diabetes?
(HealthDay)—Eating foods that contain certain nutrients may help people with newly diagnosed type 1 diabetes continue producing some insulin for as long as two years, a new study finds.

New drugs to find the right target to fight Alzheimer's disease
The future is looking good for drugs designed to combat Alzheimer's disease. EPFL scientists have unveiled how two classes of drug compounds currently in clinical trials work to fight the disease. Their research suggests that these compounds target the disease-causing peptides with high precision and with minimal side-effects. At the same time, the scientists offer a molecular explanation for early-onset hereditary forms of Alzheimer's, which can strike as early as thirty years of age. The conclusions of their research, which has been published in the journal Nature Communications, are very encouraging regarding the future of therapeutic means that could keep Alzheimer's disease in check.

Brain chemistry changes in children with autism offer clues to earlier detection and intervention
(Medical Xpress)—Between ages three and 10, children with autism spectrum disorder exhibit distinct brain chemical changes that differ from children with developmental delays and those with typical development, according to a new study led by University of Washington researchers.

New findings could help improve development of drugs for addiction
Scientists from the Florida campus of The Scripps Research Institute have described findings that could enable the development of more effective drugs for addiction with fewer side effects.

Whooping cough on the rise again
(Medical Xpress)—Whooping cough (Pertussis) is a highly contagious disease caused by the bacterium Bordetella pertussis and characterized by attacks of severe coughing, often (but not always) with a characteristic high-pitched "whoop" at the end. Until recently it appeared that the disease was close to being eradicated, but the incidence is now rapidly increasing.


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